Animal Research Cores Family

Image: Mouse intestinal lumen by Qi Yan Ang

UCSF cores facilitate research involving the use of animals. In addition to a range of services, they also offer guidance for humane care and experimental design, and, in some cases, access to external laboratories.

Contact the cores directly to see how they can help you. The list of resources on this family page is not exhaustive.

Animal Care

  • Laboratory Animal Resource Center: all issues relating to the humane care of laboratory animals -- technical, regulatory, UCSF policy

Mouse Model Generation

  • Animal Model Core: xenograft model development, intercranial tumor cell implantation
  • Cryopreservation Core: in vitro fertilization, embryo transplantation
  • ES Cell Targeting Core: knockout mice, gene targeting
  • Gladstone Transgenic Gene Targeting Core: transgenic mice, knockout mice, ES cell-derived mouse embryos and mice
  • Gnotobiotics Core: Germ-free mice and tissues
  • Laboratory Animal Resource Center: breeding
  • Preclinical Therapeutics Core (HDFCCC): xenograft-based cancer models, genetically engineered cancer models
  • Rederivation Core: embryo collection and transplantation, in vitro maturation

Metabolic and Behavioral Analyses

  • Animal Model Core: Pump implantation, convection-enhanced delivery system, in vivo imaging
  • Core center for Musculoskeletal Biology and Medicine: biostatistics, imaging, skeletal phenotyping
  • Diabetes Center Mouse Metabolism Core: bone density, fat/lean mass, metabolism
  • Gladstone Neurobehavioral Core: test and analyze cognitive, sensorimotor, social/emotional behavior
  • Laboratory Animal Resource Center: microinjection, special services
  • Mouse Physiology and Morphology Core: quantitative analysis of physiologic and morphologic studies in models of allergic asthma
  • Neurobehavioral Core for Rehabilitation Research: test and analyze phenotype mice in controlled environment
  • Preclinical Imaging Core: expertise and technical support for tissue and small animal imaging studies

Tissue Preparation and Analysis

  • Animal Model Core: cell line and primary tissue culture, tissue collection, blood collection
  • Cryopreservation Core: sperm and embryo cryopreservation
  • BIOS-HDFCCC Biorepository and Tissue Biomarker Technology Core: tissue collection and prep, blood smear prep and automated cell counting, cytospin prep and stain, external laboratory testing, consultations
  • Preclinical Therapeutics Core (HDFCCC): preparation and administration of agents, monitoring tumor burden and response to therapy, tissue collection and banking, experimental design
  • UCSF Viracore: lentiviral reagents and preparation, CRISPR libraries, AAV serotypes, training and education